Welcome to Landmark Trials

Where we collect the most impactful research within the fields of Internal Medicine

Finding the evidence

Evidence-based medicine is the best way to practice healthcare in our modern age. Have you attended rounds as a medical student or resident and heard physicians mentioning certain trials by name? Do you want to learn about some of the most important data behind the guidelines? Here at Landmark Trials we aim to help you do that! We currently have around 200 key articles cataloged and will continue to add more to this site. Click on a study title to get more information about each trial and links to their journals!

Update 5 (June 24, 2022)

Update 5 is live now! New articles that have been added are:


  • AIM-HIGH trial: Niacin for low HDL and dyslipidemia
  • AFIRE trial: Rivaroxaban for patients with Afib and stable CAD


  • DCCT/EDIC trial: Diabetes Control and Complications trial
  • Pioneer 1 trial: Semaglutide for T2DM


  • RxPONDER trial: 21-Gene Assay (Oncotype Dx) to guide chemo in breast cancer

Update 4 (Feb 6, 2022)

We have added our Learning EBM corner! We plan to use the Learn EBM page to inform our audience of some of the fundamental EBM concepts and offer resources that can be used for further education.

Update 3 (Jan 15, 2022)

Update 3 is live now! New articles that have been added are:

Pulmonology / Critical Care:

  • SYGMA 2 trial: Budesonide-Formoterol PRN for asthma
  • Reducing CLABSI trial
  • POET-COPD trial: Tiotropium for prevention of COPD exacerbations


  • POLO trial: Olaparib for BRCA-mutated pancreatic cancer


  • DAPA-HF trial: Dapagliflozin for HFrEF

Update 2 (Oct 24, 2021)

Update 2 is live now! New articles that have been added are:


  • GUSTO trial: Thrombolysis for acute myocardial infarction
  • SAVE trial: ACE-I’s for left ventricular dysfunction
  • ACUTE trial: TEE prior to cardioversion for Afib


  • Outcomes following hepatic resection/RFA for colorectal liver mets
  • BICC-C trial: FOLFIRI for colon cancer


  • Plasma exchange for TTP trial


  • IV albumin for cirrhotic paracentesis trial
  • Variceal ligation for esophageal varices bleeding prophylaxis trial


  • EDIC trial: Intensive control for Type 1 diabetics

Update 1 (Aug 28, 2021)


  • CheckMate 577 trial: Adjuvant nivolumab in resected esophageal cancer
  • CheckMate 694 trial: First line nivolumab + chemo for esophageal and GEJ cancer
  • FLAURA trial: Osimertinib for EGFR+ NSCLC
  • KEYNOTE 407 trial: Pembrolizumab + chemotherapy in squamous NSCLC


  • DPP trial: Lifestyle interventions and metformin to prevent diabetes
  • CREDENCE trial: Canagliflozin for diabetic nephropathy
  • WHI trial: HRT for post-menopausal women


  • SHEP trial: Benefit of treating HTN to reduce stroke risk
  • ACCOMPLISH trial: Benazepril + amlodipine for hypertension

How are these articles selected?

There are several ways by which we identify practice-changing studies. We review guidelines and look up their references, search for trials that resulted in FDA approval of medications, and record the names of trials frequently discussed by physicians in the hospital. Of these papers, we include the ones we feel were most important for medical trainees to know about here. We are still adding landmark studies to this site, so if you would like to suggest some to us please reach out!

Do you think there are some important trials we should add to our site? Please contact us at landmarktrials@gmail.com with the trial name, link, and why you think it is a landmark paper! Or use the form below:

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