Acute Coronary Syndrome / Coronary Artery Disease:

Aspirin and heparin in acute unstable angina 

CURE trial: Clopidogrel + aspirin in NSTEMI

CLARITY-TIMI 28 trial: Clopidogrel + aspirin and fibrinolysis in STEMI

GUSTO trial: Thrombolysis for acute myocardial infarction

TRITON-TIMI 38 trial: Prasugrel vs clopidogrel in ACS

PLATO trial: Ticagrelor vs clopidogrel in ACS

DANAMI-2 trial: PCI vs fibrinolysis in MI

COMMIT trial: Beta-blockers in patients with MI

BASKET-PROVE trial: Drug-eluting coronary stents vs bare-metal stents

TIMI score study

TIMACS trial: Early vs delayed PCI in ACS

COURAGE trial: PCI vs medical therapy for stable CAD

SYNTAX trial: PCI vs CABG for severe CAD

FREEDOM trial: Multivessel CAD in diabetics

PROVE-IT TIMI 22 trial: Intensive vs moderate statins for CAD

HOPE trial: ACE-I effect on CV outcomes

PIONEER AF-PCI trial: Rivoraxaban and antiplatelet therapy for Afib + CAD

AUGUSTUS trial: Apixaban and antiplatelet therapy for Afib + CAD

AIM-HIGH trial: Niacin for HDL levels


DASH trial: Diet for hypertension

SHEP trial: Benefit of treating HTN to reduce stroke risk

ALLHAT trial: ACE-Is, CCBs, and thiazides for hypertension

ACCOMPLISH trial: Benazepril + amlodipine for hypertension

HYVET trial: Managing hypertension in the elderly

SPRINT trial: Intensive BP control

TOHP 1 trial: Non-pharmacological interventions for BP control

IDNT trial: ARBs for diabetic nephropathy

Heart Failure

CONSENSUS trial: ACE-Is for heart failure

MERIT-HF trial: Metoprolol for heart failure

COPERNICUS trial: Carvedilol for heart failure

 Val-HEFT trial: ARB for heart failure

 SAVE trial: ACE-Is for LV dysfunction

 RALES trial: Spironolactone for heart failure

 EMPHASIS-HF trial: Eplerenone for heart failure

 A-HeFT trial: Isosorbide dinitrate and hydralazine for heart failure

 DOSE trial: Diuretics for acute heart failure

 MADIT II trial: ICD for heart failure with reduced EF

 MADIT CRT trial: CRT-D for heart failure with reduced EF

 HEARTMATE II trial: LVAD for advanced HF

 PARADIGM-HF trial: Sacubitril-valsartan for CHF

EMPEROR Reduced trial: Empagliflozin in CHF

DAPA HF trial: Dapagliflozin in CHF


AFFIRM trial: Rate control vs rhythm control for Afib

SPAF III trial: Warfarin dosing for Afib

ARISTOTLE trial: Apixaban vs warfarin for Afib

ACUTE trial: TEE for Afib cardioversion

BRIDGE trial: Perioperative anticoagulation bridging for Afib

PIONEER AF-PCI trial: Rivaroxaban + DAPT for Afib + CAD

AUGUSTUS trial: Anticoagulation + DAPT for CAD

AFIRE trial: Rivaroxaban for Afib + stable CAD

Valvular diseases

PARTNER A trial – TAVR in high-risk patients

PARTNER 3 trial – TAVR in low-risk patients

COAPT trial – Transcatheter mitral valve repair

EASE trial – Surgery for infective endocarditis

Do you think there are some important trials we should add to our site? Please contact us at with the trial name, link, and why you think it is a landmark paper!

Disclaimer: Please note that articles mentioned on this site are the property of their respective journals. The information from these articles was presented on this site under the Fair Use legal doctrine (Section 107 of the Copyright Act) as the data shared was limited in quantity, factual in nature, already published, and for the purpose of relaying and teaching socially beneficial medical knowledge. The work was attributed to the journals that published them with citations and links provided.